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 業績

　英文業績（教室員が筆頭、最終、責任著者のみ）

  1. Kiuchi Z, Nishibori Y, Kutsuna Y, Kotani M, Hada I, Kimura T, Fukutomi T, Fukuhara D, Kudo A, Takata T, Ishigaki Y, Tomosugi N, Tanaka H, Matsushima S, Ogasawara S, Hirayama Y, Takematsu H, Yan K: GLCCI1 is a novel protector against glucocorticoid-induced apoptosis in T-cell. FASEB J 33:7387-7402, 2019.
  2. Hamano S, Yamamoto A, Fukuhara D, Yan K: Serum thymus and activation-regulated chemokine level as a potential biomarker for food protein-induced enterocolitis syndrome. Pediatr Allergy Immunol 30:387-389, 2019.
  3. Kiuchi Z, Ogura M, Sato M, Kamei K, Ishikura K, Abe J, Ito S: No preventive or therapeutic efficacy of infliximab against macrophage activation syndrome due to systemic juvenile idiopathic arthritis. Scand J Rheumatol 48:246-248, 2019.
  4. Ozawa Y, Takahashi S, Miyahara H, Hosoi K, Miura M, Morisaki N, Ito Y, Isayama T: Utilizing Video versus Direct Laryngoscopy to Intubate Simulated Newborns while Contained within the Incubator: A Randomized Crossover Study. American Journal of Perinatology 2019 Mar 20. doi: 10.1055/s-0039-1683957.
  5.  Miyata Y, Saida K, Kumada S, Miyake N, Mashimo H, Nishida Y, Shirai I, Kurihara E, Nakata Y, Matsumoto N: Periventricular small cystic lesions in a patient with Coffin-Lowry syndrome who exhibited a novel mutation in the RPS6KA3 gene. Brain Dev 40:566-569, 2018.
  6. Hamano S, Nishibori Y, Hada I, Mikami N, Ito-Nitta N, Fukuhara D, Kudo A, Xiao Z, Nukui M, Patrakka J, Tryggvason K, Yan K: Association of crumbs homolog-2 with mRORC1 in developing podocyte. PLoS ONE 2018 Aug 20;13(8):e0202400. doi: 10.1371
  7. Gemma Y, Bessho F, Yoshino H: Treatment of acute lymphoblastic leukemia in Down syndrome. Cogent Medicine 4:1304512,2017.
  8. Fukuhara D, Takiura T, Keino H, Okada AA, Yan K: Iatrogenic Cushing's Syndrome Due to Topical Ocular Glucocorticoid Treatment. Pediatrics. 2017 Jan 19. pii: e20161233. doi: 10.1542.
  9. Takagi H, Nishibori Y, Katayama K, Katada T, Takahashi S, Kiuchi Z, Takahashi S, Kamei H, Kawakami H, Akimoto Y, Kudo A, Asanuma K, Takematsu H, Yan K: USP40 gene knockdown disrupts glomerular permeability in zebrafish. Am J Physiol Renal Physiol:702-715, 2017.
  10. Ito Y, Katayama K, Nishibori Y, Akimoto Y, Kudo A, Kurayama R, Hada I, Takahashi S, Kimura T, Fukutomi T, Katada T, Suehiro J, Beltcheva O, Tryggvason K, Yan K: Wolf-Hirschhorn syndrome candidate 1-like 1 epigenetically regulates nephrin gene expression. Am J Physiol Renal Physiol 312:F1184-F1199, 2017.
  11. Kutsuna S, Yonetani S, Araki K, Izumiya H: A case of pediatric patient with acute enteritis due to CTX-M-15 extended-spectrum β-lactamase-producing Salmonella Blockley. Jpn J Antibiot 69:343-346, 2016.
  12. Gordon EJ, Fukuhara D, Weström S, Padhan N, Sjöström EO, van Meeteren L, He L, Orsenigo F, Dejana E, Bentley K, Spurkland A, Claesson-Welsh L: The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation. Sci Signal 9(437):ra72, 2016.
  13. Komatsu Y, Suzuki T, Tsurusaki Y, Miyake N, Matsumoto N, Yan K: TMEM67 mutations found in a case of Joubert syndrome with renal hypodysplasia. Cen Case Rep 5:137-140, 2016.
  14. Yan K: Energy and Mammalian Target of Rapamycin Complex 1 (mTORC1) in Minimal Change Nephrotic Syndrome. In Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome: Tokyo, Springer, Kazunari Kaneko, ed. 2015, p.63-80.
  15. Fumoto S, Hosoi K, Ohnsihi H, Hoshina H, Yan K, Saji H, Oka A: Chimerism of Buccal Membrane Cells in a Monochorionic Dizygotic Twin. Pediatrics. 2014 Apr;133(4):e1097-100. doi: 10.1542
  16. Bessho　F, Takayama N, Fronkova E, Zuna J: Reappearance of acute　lymphoblastic leukemia 34 years after initial diagnosis: a case report and study of the origin of the reappeared blasts. Int J Hematol 97:525-528, 2013.
  17. Fukuhara D, Kurayama R, Ito Y, Komagata Y, Arimura Y, Yan K: Granulomatosis with polyangiitis associated with IgA nephropathy. CEN Case Reports 2:204-208, 2013.
  18.  Hara M, Yamagata K, Tomino Y, Saito A, Hirayama Y, Ogasawara S, Kurosawa H, Sekine S, Yan K: Urinary podocalyxin is an early marker for podocyte injury in patients with diabetes: establishment of a highly sensitive ELISA to detect urinary podocalyxin. Diabetologia 55:2913-2919, 2012.
  19. Ito N, Nishibori Y, Ito Y, Takagi H, Akimoto Y, Kudo A, Asanuma K, Sai Y, Miyamoto K, Takenaka H, Yan K: mTORC1 activation triggers the unfolded protein response in podocytes and leads to nephrotic syndrome. Lab Invest 91:1584-95, 2011.
  20. Kurayama R, Ito N, Nishibori Y, Fukuhara D, Akimoto Y, Higashihara E, Ishigaki Y, Sai Y, Miyamoto K, Endou H, Kanai Y, Yan K: Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis. Lab Invest 91:992-1006, 2011.
  21. Yan K, Ito N, Nakajo A, Kurayama R, Fukuhara D, Nishibori Y, Kudo A, Akimoto Y, Takenaka H: The struggle for energy in podocytes leads to nephritic syndrome. Cell Cycle 11:1504-1511, 2012.
  22. Nishibori Y, Katayama K, Parikka M, Oddsson A, Nukui M, Hultenby K, Wernerson A, He B, Ebarasi L, Raschperger E, Norlin J, Uhlén M, Patrakka J, Betsholtz C, Tryggvason K: Glcci1 deficiency leads to proteinuria. J Am Soc Nephrol 22:2037-2046, 2011.
  23. Sekine Y, Nishibori Y, Akimoto Y, Kudo A, Ito N, Fukuhara D, Kurayama R, Higashihara E, Babu E, Kanai Y, Asanuma K, Nagata M, Majumdor Å, Tryggvason K, Yan K: Amino acid transporter LAT3 is required for podocyte development and function. J Am Soc Nephrol 20:1586-1596, 2009.
  24. Shirahata A, Fujisawa K, Ishii E, Ohta S, Sako M, Takahashi Y, Taki M, Mimaya J, Kubota M, Miura T, Kitazawa J, Kajiwara M, Bessho F: A nationwide survey of newly diagnosed childhood idiopathic thrombocytopenic purpura in Japan. J Pediatr Hematol Oncol 31:27-32, 2009.
  25. Waragai T, Awa S, Akagi M, Andou Y, Watanabe N, Hosaki A, Kawamata H: Clinical implication of main pulmonary artery Windkessel size after banding operation. Pediatr Int 51:84-90, 2009.
  26. Ohnishi H, Hosoi K, Yoshino H, Sugiura M, Matsushima S, Watanabe T, Bessho F: A novel JAK2 splicing mutation in neonatal myeloproliferative disorder accompanying congenital anomalies. Br J Haematol 145:676-678, 2009.
  27. Shimizu M, Khoshnoodi J, Akimoto Y, Kawakami H, Hirano H, Higashihara E, Hosoyamada M, Sekine Y, Kurayama R, Kurayama H, Jyo K, Hirabayashi J, Kasai K, Tryggvason K, Ito N, Yan K: Expression of galectin-1, as a new component of slit diaphragm, is altered in minimal change nephritic syndrome. Lab Invest 89:178-195, 2009.
  28. Kamisaka K, Awa S, Akagi M, Watanabe N, Kato K, Waragai T: Clinical significance of reduced systemic Windkessel size in severe ventricular septal defect patients. Pediatr Int 50:322-330, 2008.
  29. Waragai A, Yamashita H, Hosoi K, Hoshina H, Noda E, Yan K, Kawano T: High-frequency oscillation (HFO) prevents activation of NF-kappaB found with conventional mechanical ventilation (CMV) in surfactant-depleted rabbit lung. Pediatr Pulmonol 42:440-445, 2007.
  30. Nakajo A, Khoshnoodi J, Takenaka H, Hagiwara E, Watanabe T, Kawakami H, Kurayama R, Sekine Y, Bessho F, Takahashi S, Swiatecka-Urban A, Tryggvason K, Yan K: Morizoribine corrects defective nephrin biogenesis by restoring intracellular energy balance. J Am Soc Nephrol 18:2554-2564, 2007.
  31. Fukuhara D, Kanai Y, Chairoungdua A, Babu E, Bessho F, Kawano T, Akimoto Y, Endou H, Yan K: Protein Characterization of Na+-Independent System L Amino Acid Transporter 3 in Mice: A Potential Role in Supply of Branched-Chain Amino Acids under Nutrient Starvation. Am J Pathol 170:888-898, 2007.
  32. Fujii Y，Khoshnoodi J，Takenaka H，Hosoyamada M，Nakajo A，Bessho F，Kudo A，Takahashi S，Arimura Y，Yamada A，Nagasawa T，Ruotsalainen V，Tryggvason K，Lee AS，Yan K：The effect of dexamethasone on defective nephrin transport caused by ER stress：A potential mechanism for the therapeutic action of glucocorticoids in the acquired glomerular diseases．Kidney Int 69:1350-1359，2006．
  33. Bessho F，Imashuku S，Hibi S，Tsuchida M，Nakahata T，Miyazaki S，Kojima S，Tsukimoto I，Hamajima N (Pediatric AA Followup Study Group in Japan)：Serial morphological observation of bone marrow in aplastic anemia in children. Intern J Hematol 81:400-404, 2005．
  34. Nishibori Y, Liu L, Hosoyamada M, Endou H, Kudo A, Takenaka H, Higashihara E, Bessho F, Takahashi S, Kershaw D, Ruotsalainen V, Tryggvason K, Khoshnoodi J, Yan K: Disease-causing missense mutations in NPHS2 gene alter normal nephrin trafficking to the plasma membrane. Kidney Int 66:1755-1765, 2004.
  35. Yan K, Khoshnoodi J, Ruotsalainen V, Tryggvason K: N-linked glycosylation is critical for the plasma membrane localization of nephrin．J Am Soc Nephrol 13:1385-1389, 2002．
  36. Kataoka S,  Kudo A, Hirano H, Kawakami H, Kawano T, Higashihara E, Tanaka H, Delarue F, Sraer JD, Mune T, Krozowski ZS, Yan K: 11beta-hydroxysteroid dehydrogenase type 2 is expressed in the human kidney glomerulus．J Clin Endocrinol Metab 87:877-82, 2002．
  37. Yoshino H, Ueda T,Ebihara Y, Manabe A, Tanaka R, Kobayashi K, Ito M, Asano S, Nakahata T, Tsuji K: Natural killer cell depletion by anti-asialo GM1 antiserum treatment enhances human hematopoietic stem cell engraftment in NOD/Shi-scid mice. Bone Marrow Transplant 26:1211-1216, 2000.
  38. Watanabe N, Awa S, Akagi M, Ando Y, Oki N, Waragai T, Hosaki A, Kawamata H, Kamisaka K: Effects of heart rate and right ventricular pressure on right coronary arterial flow and its systolic versus diastolic distribution in a variety of congenital heart diseases in children. Pediatr Int 42:476-482, 2000.
  39. Nakajima N, Sekine T, Cha SH, Tojo A, Hosoyamada M, Kanai Y, Yan K, Awa S, Endou H: Developmental changes in multispecific organic anion transporter 1 expression in the rat kidney. Kidney Int 57:1608-1616, 2000.
  40. Yan K, Kudo A, Hirano H, Watanabe T, Tasaka T, Kataoka S, Nakajima N, Nishibori Y, Shibata T, Kohsaka T, Higashihara E, Tanaka H, Watanabe H, Nagasawa T, Awa S: Subcellular localization of glucocorticoid receptor protein in the human kidney glomerulus. Kidney Int 56:65-73, 1999.
  41. Sakai T, Matsuda H, Nirasawa Y: Point mutation in Exon 12 of the receptor kinase　proto-oncogene RET in Ondine=Hirschsprung sundrome. Pediatrics 101:924-926, 1998.
  42. Yan K, Nakahara K, Awa S, Nishibori Y, Nakajima N, Kataoka S, Maeda M, Watanabe T, Matsushima S, Watanabe N: The increase of memory T cell subsets in children with idiopathic nephrotic syndrome. Nephron 79:274-278, 1998.
  43. Yan K, Nakamura Y, Watanabe N, Kawato H, Fujimiya Y, Kohsaka T: Regulation of C3 production by interferon-gamma from peripheral blood T cells in patients with membranoproliferative glomerulonephritis and poststreptococcal acute glomerulonephritis. Nephron 72:623- 628, 1996.
  44. Oki N, Awa S: Dependence of canine right coronary arterial flow upon heart rate and right ventricular pressure. Acta Paediatr Jpn 37:450-757, 1995.
  45. Kobayashi T, Tanaka S, Maeda M, Okubo H, Matsuyama T, Watanabe N: A study of prognosis in 52 cases with juvenile rheumatoid arthritis. Acta Paediatr Jpn 35:439-446, 1993.

 

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